I have a 4.5 year old son and an almost 3 year old daughter who both occasionally wet the bed. And of course they both usually wet the bed on the same night. I swear they're out to get me sometimes! Anyway, they both went through a phase a few months ago where they were wetting the bed almost every single night. We'd just come back from a month-long vacation, just moved into our new house, etc, so they were really off schedule. Even so, I was about ready to lose my mind!
The real problem was when I'd strip their bedding and put it in the laundry room, but then I'd get busy and forget to wash or dry it before nap or bedtime. Then I didn't have their mattress protectors for their beds or any of their bedding. I was getting so frustrated because I detest being "forced" to do laundry like that.
Then I had a brilliant idea! It has seriously saved me so much energy and sanity. I bought an extra mattress protector and an extra set of sheets for each of their beds. I make their beds with 2 sets of everything. So it goes like this: mattress protector, fitted sheet, flat sheet, mattress protector, fitted sheet, flat sheet, comforter. When they do have an accident, I just strip the top layer of the bedding off, and their beds are all ready to go again!